Fundamental aspects of solid dispersion technology for poorly soluble drugs.
10.1016/j.apsb.2013.11.001
- Author:
Yanbin HUANG
1
;
Wei-Guo DAI
2
Author Information
1. Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
2. Janssen Research and Development, Johnson & Johnson Company, Randor 19087, PA, USA.
- Publication Type:Journal Article
- Keywords:
Drug–polymer interaction;
Phase separation;
Poorly soluble drug;
Solid dispersion
- From:
Acta Pharmaceutica Sinica B
2014;4(1):18-25
- CountryChina
- Language:English
-
Abstract:
The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug-polymer two-component system, the drug-polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology.
