Quantifying the Cerebral Hemodynamic Changes in Hypertensive Patients Using 3D Pseudo-continuous Arterial Spin Labeling.
10.3881/j.issn.1000-503X.2017.04.004
- VernacularTitle:三维准连续式动脉自旋标记灌注成像在定量高血压患者脑血流动力学变化中的应用
- Author:
Ting WANG
1
;
Yan-Hua LI
2
;
Xin-Hong GUO
2
;
Lin MA
1
;
Xin LOU
1
Author Information
1. Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
2. Department of Cardiology,Chinese PLA General Hospital,Beijing 100853,China.
- Publication Type:Journal Article
- From:
Acta Academiae Medicinae Sinicae
2017;39(4):477-484
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the cerebral hemodynamic changes in hypertensive patients using 3D pseudo-continuous arterial spin labeling(3D pCASL).Methods Fifty-eight hypertensive subjects and thirty-four age-matched healthy volunteers were recruited and scanned using the 3D whole-brain pCASL sequence.The regional cerebral blood flow(CBF)values were achieved based on 3D pCASL with SPM8 technique and were manually drawn. Results Compared with healthy volunteers,hypertensive patients had significantly lower CBF values in various regions,with statistical difference at the bilateral centrum semiovale(P=0.000,P=0.000),periventricular white matter(P=0.001,P=0.002),splenium of corpus callosum(P=0.003),frontal lobe(P=0.003),parietal lobe(P=0.014),occipital lobe(P=0.002),temporal lobe(P=0.006),medulla(P=0.012),pons(P=0.016),midbrain(P=0.034),cerebellum(P=0.000),and gray matter(P=0.001).Nevertheless,the CBF values in the thalami,globus pallidus,putamen,and genu of corpus callosum demonstrated no significant inter-group difference(all P>0.05).Conclusions 3D pCASL can be used to detect the subtle hemodynamic abnormalities even at the early stage of hypertension.The observed decrease in CBF in these regions may suggest an increased risk of cerebral small vessel diseases.
