Clinical and laboratory investigation of patients with hematologic malignancies harboring der(1;7)(q10;p10).
- VernacularTitle:21例伴有der(17)(q10;P10)的恶性血液病患者临床及实验室研究
- Author:
Fang-yun XU
1
;
Xu-ping LIU
;
Cheng-wen LI
;
Shuang QIN
;
Wan-chen SUN
;
Wen CUI
;
Ying-chang MI
;
Ren-chi YANG
;
Jian-xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Chromosomes, Human, Pair 1; genetics; Chromosomes, Human, Pair 7; genetics; Female; Hematologic Neoplasms; genetics; therapy; Humans; Laboratories; Male; Middle Aged; Recurrence; Translocation, Genetic; genetics; Treatment Outcome; Young Adult
- From: Chinese Journal of Medical Genetics 2011;28(4):441-445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical and laboratory characteristics of patients with various hematological malignancies harboring der(1;7)(q10;p10).
METHODSBone marrow samples were collected and undergone short-time unstimulated culture and R-banding, and karyotyped by conventional cytogenetic assay (CCA). Megalokaryocytes were detected by streptavidin-AKP (SAP). Retrospective analyses including the clinical and laboratory data were performed.
RESULTSNineteen of the 21 patients were male. Most of the patients are of older age. Thirteen cases (61.9%) were der(1;7)(q10;p10) without additional aberrations, 8(38.1%) patients had additional aberrations. Sixteen out of the 18 cases (88.9%) who underwent SAP analysis had diminutive megalokaryocyte, and lymphoid megalokaryocyte was found in 10 cases (55.6%). The der(1;7) patients manifested poor response to treatment.
CONCLUSIONThe der(1;7) patients demonstrated distinct male predominance, older age at diagnosis, and some clinically distinctive features. These patients showed poor prognosis. The cytogenetic abnormality, i.e., der(1;7)(q10;p10), can be used as a prognostic indicator.
