Distributional characteristics of acylation stimulating protein gene 301T ＞C polymorphism and association with serum triglyceride in Han and Uighur residents in Xinjiang
10.3760/cma.j.issn.0253-3758.2012.11.008
- VernacularTitle:新疆维、汉民族促酰化蛋白基因301T＞C多态性分布特征及其与血脂的关系
- Author:
Si-Jin YANG
1
;
Yi-Tong MA
;
Xiang XIE
;
Yi-Ning YANG
;
Xiang MA
;
Xiao-Mei LI
;
Fen LIU
Author Information
1. 新疆医科大学第一附属医院心脏中心
- Keywords:
Acylation stimulating protein;
Polymorphism,single nucleotide;
Uighur;
Han
- From:
Chinese Journal of Cardiology
2012;40(11):929-932
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distributional characteristics of acylation stimulating protein (ASP) gene polymorphism and the association with serum lipid level of Chinese Han and Uighur residents in Xinjiang.Method Genotypes of the ASP gene 301T ＞ C polymorphism was detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in 527 Uighur and 407 Han residents.Results The frequencies of TT,TC and CC genotype of ASP gene 301T ＞ C were 74.9％,21.3％ and 3.6％ in Han group and 47.6,40.2％ and 12.1％ in Uighur group(P ＜0.05).Serum triglyceride level was significantly higher in C allele carrier (TC + CC genotype)than in TT genotype carrier of both Han and Uighur individuals.After adjusting for age,gender,smoking,drinking,BMI and serum total cholesterol,logistic regression analyses revealed that individuals carrying C allele (TC + CC genotype) faced an increased risk of increased serum triglyceride level than individuals carrying TT genotype in both Han and Uighur individuals (OR =3.31,95 ％ CI:1.31-8.36 in Uighur group ; OR =3.98,95 ％ CI:1.81-8.74in Han group).Conclusion There is a significant difference on mutational frequencies of the ASP gene 301T ＞ C polymorphism between Uighur and Han residents in Xinjiang and C allele carriers face an increased risk for hypertriglyceridemia in both Uighur and Han residents in Xinjiang.
