Relationship between inflammatory cytokines of IL-1β and TNF-α and intervertebral disc degeneration.
10.3969/j.issn.1003-0034.2017.09.017
- VernacularTitle:炎性因子IL-1β、TNF-α与椎间盘退变关系的研究进展
- Author:
He ZHAO
1
;
Xing YU
2
;
Xian-Sheng TANG
1
;
Feng HE
1
;
Yong-Dong YANG
1
;
Yang XIONG
1
;
Zhen-Guo HU
1
;
Lin XU
1
Author Information
1. Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China.
2. Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China;yuxing34@sina.com.
- Publication Type:Journal Article
- Keywords:
Cell signaling pathways;
IL-1β;
Inflammatory cytokines;
Intervertebral disc degeneration;
TNF-α
- From:
China Journal of Orthopaedics and Traumatology
2017;30(9):866-871
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory cytokines of IL-1β and TNF-α participate in the process of intervertebral disc degeneration is focused by the spine surgeons. Inflammatory cytokines represented by IL-1β and TNF-α act as the key factors in the process of intervertebral disc degeneration resulting in low back pain and radicular symptoms. Annulus fibrosus and nucleus pulposus can secrete TNF-α and IL-1β under the stimulation of mechanical injury, overstressed, genetic susceptibility and infection. The mechanism of inflammatory cytokines in intervertebral disc degeneration needs further investigation. The emphasis of researches will be on the inflammatory cytokines in the regulation of mechanism in the intervertebral disc degeneration, molecular targeted therapy, cell signaling pathways and the best time of anti-inflammatory therapy providing more evidence in the clinical application.
