Effects of antihypertensive drugs on erectile function and number of nNOS-containing nerve fibers in spontaneously hypertensive rats.
- Author:
Jian-Li CHENG
1
;
Li-Quan HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antihypertensive Agents; pharmacology; therapeutic use; Hypertension; drug therapy; Male; Nerve Fibers; enzymology; Nitric Oxide Synthase; metabolism; Nitric Oxide Synthase Type I; Penile Erection; drug effects; Penis; drug effects; physiology; Rats; Rats, Inbred SHR
- From: National Journal of Andrology 2003;9(2):115-117
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo investigate the effects of antihypertensive drugs on the erectile function and number of nNOS-containing nerve fibers in spontaneously hypertensive rats(SHRs).
METHODSEighteen male SHRs of six-weeks old were randomized into three groups: Vilsartan intervention group, Aldactone intervention group and control group. Vilsartan [30 mg/(kg.d)] and Aldactone [20 mg/(kg.d)] were administered by gavage to respective groups. After twelve weeks treatment, all SHRs were tested for erectile function and then killed for the detection of nNOS-containing nerve fibers by Streptaridin-peroxidase immunohistochemistry techniques (SP method).
RESULTSThe erection frequency in Vilsartan group was higher, compared with other two groups(P < 0.05), in which no significant difference was observed (P > 0.05). There was no significant difference in erection rates among these three groups. The number of nNOS-containing nerve fibers in two intervention groups was higher than the control group(P < 0.01), but no significant difference existed between these two groups(P > 0.05).
CONCLUSIONSVilsartan improves erectile function in SHRs while Aldactone doesn't. The difference can't be explained by the number of nNOS-containing nerve fibers, and it is probably related to the vascular reconstruction induced by angiotensin II receptor antagonists.
