Study on percutaneous absorption of xiaozheng zhitong cataplasm.

Author: Yan-Ju BAO ^{1
,

2} ; Mao-Bo DU ³ ; Shu-Zhi LIU ³ ; Bao-Jin HUA ⁴
Author Information

1. Guang'anmen Hospital, China Academy of Chinese Medical Science, Belting 100053, China. baoyanju@
2. com
3. Institute of Chinese Medicine, China Academy of Chinese Medical Science, Beijing 100700, China.
4. Guang'anmen Hospital, China Academy of Chinese Medical Science, Belting 100053, China.
Publication Type:Journal Article
MeSH: Administration, Cutaneous; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Female; Permeability; Rats; Rats, Wistar; Skin Absorption
From: China Journal of Chinese Materia Medica 2013;38(22):3907-3909
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the transdermal behavior of Xiaozheng Zhitong cataplasm in rats.
METHODWith tetrahydropalmatine as the index, the Franz diffusion cell method was adopted for the experiment. Sample content was determined with HPLC.
RESULTThe transdermal permeability and the transmission rate of tetrahydropalmatine accumulated for 24 h were 20.20% and 0.744 1 microg x cm(-2) x h(-1), respectively.
CONCLUSIONThe transdermal behaviors of Xiaozheng Zhitong cataplasm were ideal in conformity with the zero order kinetic model.