Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort.
- Author:
Eleni P KATANA
1
;
Lemonia G SKOURA
;
Zacharias G SCOURAS
;
Michail A DANIILIDIS
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Gene Frequency; Genotype; Greece; Heme Oxygenase-1; genetics; Humans; Male; Microsatellite Repeats; genetics; Middle Aged; Polymorphism, Genetic; genetics; Promoter Regions, Genetic; genetics; Young Adult
- From: Chinese Medical Journal 2011;124(20):3408-3411
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDHeme oxygenase-1 (HO-1) is an enzyme, which catabolizes heme into carbon monoxide, biliverdin and free iron. The induction of this enzyme is an important cytoprotective mechanism, which occurs as an adaptive and beneficial response to a wide variety of oxidant stimuli. HO-1 inducibility is mainly modulated by a (GT)(n) polymorphism in the promoter region, and has been shown that short (S) repeats are associated with greater up-regulation of HO-1, compared with long (L) repeats.
METHODSIn the present study, 250 healthy Greek individuals have been screened in order to estimate the frequencies of (GT)(n) alleles in the HO-1 gene.
RESULTSNineteen different alleles, ranging from 17 to 39 repeats, with (GT)(23) and (GT)(30) being the most common ones, were identified.
CONCLUSIONThe possible role of this polymorphism in disease states is discussed.
