Study on solid dispersion of copovidone-based tanshinone II(A).
- Author:
Yan-Rong JIANG
1
,
2
;
Zhen-Hai ZHANG
;
Hai-Jiang XIA
;
Xiao-Bin JIA
Author Information
- Publication Type:Journal Article
- MeSH: Biological Availability; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; methods; Diterpenes, Abietane; chemistry; Drug Carriers; chemistry; Drugs, Chinese Herbal; chemistry; Microscopy, Electron, Scanning; Pharmaceutical Preparations; chemistry; Pyrrolidines; chemistry; Solubility; Time Factors; Vinyl Compounds; chemistry; Water; chemistry
- From: China Journal of Chinese Materia Medica 2013;38(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo apply PVP-S630 in the preparation of tanshinone II(A) (TS II(A)) solid dispersion, in order to improve its dissolution in vitro and reduce the moisture absorption of the solid dispersion.
METHODTanshinone II(A) solid dispersion was prepared by spray drying method. Such analytical methods as SEM, DSC, XRD were used to characterize their phases and detect their dissolution, moisture absorption and stability.
RESULTIn the solid dispersion prepared with tanshinone II(A) and copovidone with proportion of 1:10, tanshinone II(A) was scattered on the surface of the carrier in the amorphous form, with a dissolution in vitro up to 100% at 0.5 h and a lower moisture absorption than PVP-K30 solid dispersion prepared with the same proportion. After a three-month accelerated stability test, it showed no significant change in drug dissolution and content.
CONCLUSIONThe solid dispersion prepared with copovidone as the carrier can significantly improve the dissolution of tanshinone II(A), with a relatively low moisture absorption and high stability, thereby having a good prospect of application.
