The effect of aluminum adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine

VernacularTitle:铝佐剂和免疫程序对Sabin IPV免疫原性影响的研究
Keywords: Poliovirus vaccine,inactivated; Aluminum hydroxide; Adjuvants,immunologic; Immunization schedule; Neutralization tests
From: Chinese Journal of Experimental and Clinical Virology 2013;27(2):102-104
CountryChina
Language:Chinese
Abstract: Objective To study the effect of aluminume adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine.Methods Four batches of Sabin IPV were produced by different concentrations of type1,2,and 3 poliovirus and administrated on three-dose schedule at 0,1,2 months and 0,2,4 months on rats.Serum samples were collected one month after each dose and neutralizing antibody titers against three types poliovirus were determined by micro-neutralization assay.Results The GMTs of neutralizing antibodies against three types poliovirus increased significantly and the seropositivity rates were 100％ in all groups after 3 doses.There was no significant difference between two immunization schedules,and the 0,2,4 month schedule could induce higher level neutralizing antibody compared to the 0,1,2 month schedule.The groups with aluminum adjuvant could induce higher level neutralizing antibody compared to the groups without adjuvant.Conclusion Aluminum djuvant and immunization schedule could improve the immunogenicity of Sabin IPV.