Advances in studies on pharmacokinetics of aristolochic acid I.
- Author:
Guan WANG
1
;
Zhi-Min WANG
;
Qi-Shi SUN
Author Information
1. School of Traditional Chinese Material Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Aristolochia;
chemistry;
Aristolochic Acids;
administration & dosage;
isolation & purification;
pharmacokinetics;
toxicity;
Dose-Response Relationship, Drug;
Humans;
Injections, Intravenous;
Kidney;
metabolism;
Kidney Diseases;
chemically induced;
Lactams;
metabolism;
toxicity;
Liver;
metabolism;
Plants, Medicinal;
chemistry;
Tissue Distribution
- From:
China Journal of Chinese Materia Medica
2006;31(19):1573-1575
- CountryChina
- Language:Chinese
-
Abstract:
Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the low dose group eliminates more quickly than the high dose group. The characters of pharmacokinetics of AA-I induce the cumulation of AA-I in vivo and the nephrotoxin to the kidney and other viscera.
