Expression of Survivin, CDK4, Ki-67 and Clinical Significance in Pediatric Acute Leukemia
- Author:
Liuqing ZHANG
1
;
Jing LIU
;
Hanhua LIN
;
Qun HU
;
Aiguo LIU
;
Ying HU
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
Survivin;
CDK4;
Ki-67;
acute leukemia;
immunohistochemistry
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(5):552-554
- CountryChina
- Language:Chinese
-
Abstract:
The expression of Survivin, CDK4 and Ki-67 and the clinical significance in pediatric acute leukemia (AL) were investigated. The expression of Survivin, CDK4 and Ki-67 proteins was detected by using immunohistochemical assay in 37 children with AL and 10 children with normal bone marrow as controls. The positive expression rate of Survivin, CDK4 and Ki-67 was 45.9 %,56.8 %, and 40.5 % respectively in 37 AL children, which was significantly higher than in control group accordingly (P＜0.05). The expression of Survivin was positively correlated with CDK4(P=0.007) and Ki-67 (P=0.008). In conclusion, all Survivin, CDK4 and Ki-67 proteins are over-expressed in pediatric AL and involved in the modulation of apoptosis and proliferation in pediatric AL.
