Role of Autophagy in Acute Lymphoblastic Leukemia -Review.
10.7534/j.issn.1009-2137.2016.06.054
- Author:
Qiong LIAO
1
;
Xia REN
2
;
Guo-Sheng JIANG
2
;
Author Information
1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China; Institute of Basic Medicine, Shandong Academy of Medical Sciences, Key Laboratory for Modern Medicine and Technology of Shandong Province; Key Medical Laboratory for Tumor Immunology & Chinese Medicine Immunology of Shandong Province, Jinan 250062, Shandong Province, China.
2. Institute of Basic Medicine, Shandong Academy of Medical Sciences, Key Laboratory for Modern Medicine and Technology of Shandong Province
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2016;24(6):1905-1908
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is an evolutionarily highly conservative lysosomal degradative process and closely associates with pathogenesis, process, treatment, drug resistance and relapse of acute lymphoblastic leukemia (ALL). Whether the autophagy displays resistance to chemotherapy or a tumor suppressor in ALL, it mainly depends on the context of autophagy in the cells. Understanding the different role of autophagy in different conditions for ALL, determing the autophagy signaling pathways and targeting combination with autophagy revulsants or inhibitors were significant for the therapy of ALL, particularly for the treatment of refractory/relapsed ALL patients. This review summarizes the role of autophagy in pathogenesis, developmant, drug resistance and treatment of ALL, providing some theoretical guidance of new drugs targeting autophagy for ALL therapy.
