Research Progress of Novel Small Molecule Drugs in the Treatment of Chronic Lymphocytic Leukemia -Review.
10.7534/j.issn.1009-2137.2017.01.044
- VernacularTitle:新型小分子药物在治疗慢性淋巴细胞白血病中的研究进展
- Author:
Jing-Qiao QIAO
1
;
Miao HE
1
;
Shu-Ting ZHANG
1
;
Hai BAI
2
Author Information
1. Hematology Center, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
2. Hematology Center, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China. E-mial: baihai98@tom.com.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2017;25(1):244-248
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lymphocytic leukemia (CLL), the most frequent adult leukemia in Western population, is characterized by accumulation of mature-looking CD5/19/23B cells in peripheral blood, bone marrow, and lymphatic organs. Over the last 20 years, there has been a dramatic change in therapy for CLL, the complete response rate increased from the initial <5% to the current 40%-50%, this remarkable improvement has been attributable to combination of chemoimmunotherapy agents that have contributed to the backbone of therapy for patients with CLL. Especially over the past 5 years, there has been an explosion of new active agents that provide a very effective solution for patients with recurrent/refractory disease as well as those who harbor poor cytogenetic abnormalities. This review focuses on some of the novel small molecule drugs that have either been approved or are at the forefront of clinical development in the treatment of patients with CLL, including tyrosine kinase inhibitior ibrutinib, PI3K inhibitor idelalisib, Syk inhibitor, BCL-2 inhibitor and so on.
