Diagnostic Value of Cerebrospinal Fluid T-SPOT.TB for Tuberculousis Meningitis in China.

Xue Lian LI; Na XIE; Song Wang WANG; Qian Hong WU; Yan MA; Wei SHU; Hong Mei CHEN; Li Qun ZHANG; Xiao Guang WU; Li Ping MA; Nan Ying CHE; Meng Qiu GAO

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Diagnostic Value of Cerebrospinal Fluid T-SPOT.TB for Tuberculousis Meningitis in China.

Author: Xue Lian LI ¹ ; Na XIE ² ; Song Wang WANG ³ ; Qian Hong WU ⁴ ; Yan MA ² ; Wei SHU ² ; Hong Mei CHEN ² ; Li Qun ZHANG ² ; Xiao Guang WU ² ; Li Ping MA ² ; Nan Ying CHE ² ; Meng Qiu GAO ² ;
Author Information

1. Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
2. Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
3. Public Health Monitor and Information Service Center, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
4. Department of Tuberculosis, Prevention and Treatment Hospital of Shanxi Province, Xian 710100, Shanxi, China.
Publication Type:Journal Article
Keywords: Cerebrospinal fluid; Diagnosis; T-SPOT.TB; Tuberculous meningitis
MeSH: China; epidemiology; Humans; Sensitivity and Specificity; Tuberculosis, Meningeal; cerebrospinal fluid; diagnosis; epidemiology
From: Biomedical and Environmental Sciences 2017;30(9):681-684
CountryChina
Language:English
Abstract: The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients (54.2%) of the 96 enrolled patients. The area under the curve (AUC) was 0.910, and the sensitivities of CSF T-SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T-SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.