Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials.
10.1016/j.apsb.2016.01.007
- Author:
Eun Ji HONG
1
;
Dae Gun CHOI
1
;
Min Suk SHIM
1
Author Information
1. Division of Bioengineering, Incheon National University, Incheon 406-772, Republic of Korea.
- Publication Type:Journal Article
- Keywords:
Cancer therapy;
Inorganic nanomaterials;
Nanoparticles;
Near-infrared light;
Organic nanomaterials;
Photodynamic therapy;
Photosensitizer;
Targeted therapy
- From:
Acta Pharmaceutica Sinica B
2016;6(4):297-307
- CountryChina
- Language:English
-
Abstract:
Photodynamic therapy (PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer (PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applications are still hampered by poor water solubility and tissue/cell specificity of conventional PS drugs. Therefore, great efforts have been made towards the development of nanomaterials that can tackle fundamental challenges in conventional PS drug-mediated PDT for cancer treatment. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with PS drugs, for significantly enhanced efficacy and tumor-selectivity of PDT.
