Therapeutic Effect of Recombinant Human Stem Cell Factor on Rhesus Monkeys with Severe Acute Radiation Sickness.
- VernacularTitle:重组人干细胞因子对重症急性放射病猴的治疗作用研究
- Author:
Fang-Min WANG
1
;
Guo-Lin XIONG
2
;
Xing SHEN
2
;
Ling XIE
2
;
Ming LI
2
;
Ling-Ling GUO
2
;
Rui-Ying ZHANG
3
;
Lu ZHANG
3
;
Xin-Ru WANG
3
;
Yu-Wen CONG
2
;
Zu-Yin YU
4
,
5
;
Shuang XING
5
,
6
Author Information
- Publication Type:Journal Article
- From: Journal of Experimental Hematology 2017;25(5):1544-1549
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effect of rhSCF early administration on rhesus monkeys with severe acute radiation sickness(ARS).
METHODSTwelve adult monkeys totally exposed to 7.0 GyCo were divided into radiation control and SCF groups, and monkeys in SCF group were subcutaneously injected recombinant human SCF(rhSCF) 200 µg/kg at half an hour and 24 hour after irradiation, while the radiation control monkeys were injected physiological saline. Survival was monitored and hematopoiesis was evaluated at 40 days following early treatment.
RESULTS6 animals treated with rhSCF all survived, while 2 in irradiated controls survived on 40 day after radiation. rhSCF treatment promoted hematopoiesis recovery significantly, increased the nadir of white blood cells, neutrophils and platelets, and simplified supportive care in ARS rhesus monkeys.
CONCLUSIONRhSCF injection soon after TBI taken shows an significant therapeutic efficiency on rhesus monkeys with severe acute radiation sickness.
