Expression of Integrin-а3 mRNA in Meningiomas and Its Correlation with Proliferation and Invasion
- Author:
CHEN JIAN
1
;
XU XIANPING
;
WANG HEPING
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
integlins;
meningiomas;
Ki-67;
in situ hybridization;
immunohistochemistry
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(1):94-96
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of integdn-а3 mRNA in meningiomas and its correlation hybridization in patients with meningiomas (36 cases) and normal dura (2 cases) and arachnoid tis-sues (2 cases).SABC immunohistochemical assay was used to study the expression of Ki-67 nuclear antigen.The results showed that the expression of integdn-a3 mRNA in benign,atypical and malig-nant meningiomas was 2.52i-0.362,1.75±0.316 and 1.42±0.633,respectively.The expression levels invasive biological behavior was lower than that in those without invasion (I.63±0.462 vs.Ki-67 labeling index in all cases.It suggested that integrin-a3 subunit participated in the modulatory process of growth of meningiomas.The proliferation activity and malignant grade of meningiomas
