Effects of exercise on neurogenesis in the dentate gyrus and ability of learning and memory after hippocampus lesion in adult rats.
- Author:
Lin CHEN
1
,
2
;
E-mail: JIANGXINGHONG@SUDA.EDU.CN
2
,
3
;
Shan GONG
;
Li-Dong SHAN
;
Wei-Ping XU
;
Yue-Jin ZHANG
;
Shi-Yu GUO
;
Tadashi HISAMITSU
;
Qi-Zhang YIN
;
Xing-Hong JIANG
Author Information
1. Department of Neurobiology, School of Medicine, Soochow University, Suzhou 215123; Department of Physiology, School of Preclinic Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China; Department of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan; E-mail: jiangxinghong@suda.edu.cn; cllc2002@
2. com.
3. ;cllc2002@
- Publication Type:Journal Article
- From:
Neuroscience Bulletin
2006;22(1):1-6
- CountryChina
- Language:English
-
Abstract:
Objective To explore the effects of exercise on dentate gyrus (DG) neurogenesis and the ability of learning and memory in hippocampus-lesioned adult rats. Methods Hippocampus lesion was produced by intrahippocampal microinjection of kainic acid (KA). Bromodeoxyuridine (BrdU) was used to label dividing cells. Y maze test was used to evaluate the ability of learning and memory. Exercise was conducted in the form of forced running in a motor-driven running wheel. The speed of wheel revolution was regulated at 3 kinds of intensity: lightly running, moderately running, or heavily running. Results Hippocampus lesion could increase the number of BrdU-labeled DG cells, moderately running after lesion could further enhance the number of BrdU-labeled cells and decrease the error number (EN) in Y maze test, while neither lightly running, nor heavily running had such effects. There was a negative correlation between the number of DG BrdU-labeled cells and the EN in the Y maze test after running. Conclusion Moderate exercise could enhance the DG neurogenesis and ameliorate the ability of learning and memory in hippocampus-lesioned rats.
