The involvement of galectin-1 in implantation and pregnancy maintenance at the maternal-fetal interface.
- Author:
Minyue TANG
1
;
Yimin ZHU
2
Author Information
1. Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
2. Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. zhuyim@zju.edu.cn.
- Publication Type:Journal Article
- From:
Journal of Zhejiang University. Medical sciences
2017;46(3):321-327
- CountryChina
- Language:Chinese
-
Abstract:
As a member of galectins family, galectin-1(Gal-1)is widely expressed in tissues and cells, and participates in a variety of physiological and pathological processes, such as cell adhesion, proliferation, apoptosis and inflammatory reaction. Recently, it has been found that Gal-1 is highly expressed at the maternal-fetal interface and plays important roles in trophoblast cell proliferation, differentiation and invasion, endometrial receptivity, placental angiogenesis and maternal-fetal immune tolerance. In this review, we outline the expression of Gal-1 at the maternal-fetal interface and the involvement of Gal-1 in embryo implantation and pregnancy maintenance, to provide novel insights for the early diagnosis, prognostic assessment and treatment of early pregnancy loss and pregnancy-related diseases.
