Value of coagulation function and fibrinolytic system assessment in patients with gestational diabetes mellitus.
- Author:
Bao-Ying LIU
1
;
Yi-Lan JIAN
;
Mei ZHONG
;
Yan-Hong YU
;
Qian WANG
;
Jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Blood Coagulation; physiology; Diabetes, Gestational; blood; physiopathology; Endothelium, Vascular; physiopathology; Female; Fibrin Fibrinogen Degradation Products; analysis; Fibrinolysis; physiology; Humans; P-Selectin; blood; Plasminogen Activator Inhibitor 1; blood; Platelet Activation; physiology; Pregnancy; Pregnancy Trimester, Third; blood; Tissue Plasminogen Activator; blood; von Willebrand Factor; analysis
- From: Journal of Southern Medical University 2007;27(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical implications of changes of coagulation function and fibrinolytic system in patients with gestational diabetes mellitus (GDM).
METHODSTwenty non-pregnant women, 20 with normal pregnancy and 46 with GDM were enrolled in this study for examinations of platelet alpha-granule membrane protein (GMP-140), Von Willebrand factor (vWF), antithrombin III activity (AT-III), plasminogen activity (PLG), activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI).
RESULTSvWF, GMP-140, PLG, D-dimer, PAI were obviously elevated while t-PA was lower in GDM patients as compared with the measurement in non-pregnant women and women with normal pregnancy (P<0.01). AT-III and ProC measurement showed no significant differences between GDM patients and women of the other two groups.
CONCLUSIONGDM patients may have elevated platelet activation and fibrinolyic activity as well as vascular endothelial injuries, and antenatal assessment of the coagulation function can be of value for prevention and treatment of GDM.
