Association between estrogen receptor beta gene polymorphisms in Chinese Uygur patients and intrahepatic cholestasis of pregnancy.
- VernacularTitle:维吾尔族雌激素β受体基因多态性与妊娠期肝内胆汁淤积症的相关性分析
- Author:
Yan YIN
1
;
Fang LI
;
Dong-mei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; Cholestasis, Intrahepatic; genetics; Estrogen Receptor beta; genetics; Female; Genetic Predisposition to Disease; Humans; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; genetics
- From: Chinese Journal of Medical Genetics 2012;29(3):319-322
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between estrogen receptor beta gene (ERβ) polymorphisms and intrahepatic cholestasis of pregnancy (ICP) in Chinese Uygur patients.
METHODSA total of 105 ICP patients and 105 healthy controls were recruited from April 2008 to April 2011. Polymorphisms of rs1256049 (Rsa I) and rs4986938 (Alu I) in ERβ gene were analyzed with PCR-restriction fragment length polymorphism (RFLP) method.
RESULTSThe frequencies of R allele were, respectively, 35.71% and 50.95% in ICP patients and controls. Odds ratio (OR) was 0.535 [95% confidence intervals (CI) = 0.3619-0.7910, P< 0.01]. Frequencies of A allele were, respectively, 21.43% and 10.95% in the patient and control groups. OR was 2.2174 (95% CI = 1.2866-3.8215, P<0.05).
CONCLUSIONERβ gene polymorphisms are associated with ICP. R allele may confer a protective effect, whilst A allele may be a risk factor.
