Associations of blood pressure level with carotid intima-media thickness and plaque among middle-aged and elderly Chinese hypertensives
10.3760/cma.j.issn.0253-3758.2013.03.017
- VernacularTitle:中老年高血压人群颈动脉内膜-中膜厚度及斑块与血压的关联性
- Author:
Ru-Xue WANG
1
;
Jun ZHA
;
Zheng-Rong XU
Author Information
1. 222100,江苏省连云港圣安医院心血管内科
- Keywords:
Hypertension;
Tunica intima;
Carotid arteries
- From:
Chinese Journal of Cardiology
2013;41(3):256-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the associations of blood pressure (BP) level with carotid intimamedia thickness (CIMT) and plaque in a middle-aged and elderly hypertensive population.Methods By block randomized sampling,an epidemiological investigation was conducted among hypertensives aged 45-75 years in the northeru rural area of Jiangsu Province.Blood pressure was measured,and carotid CIMT and plaquc were determined using a coloured ultrasonograph.The relationship between blood pressure level and CIMT or plaque was analyzed using a multivariable linear regression or logistic regression model.Results A total of 524 subjects (male 242) were enrolled.CIMT and plaque prevalence were (0.7 ± 0.1) mm and 46.3％ in males and (0.7 ± 0.1)mm and 34.0％ in females.After adjustment for relevant variables,CIMT increased 0.001 12 mm with 1 mmHg systolic BP increase in males (P ＜ 0.001) but this trend was not significant in females.The risk of plaque number ＞ 1 was significantly higher in those with grade Ⅲ hypertension compared to grade I hypertensives (OR:2.136,95％ CI:1.138-4.012,P =0.018).Conclusion In this middle-aged and elderly hypertensive population,carotid CIMT is positively in relation to systolic BP,especially for male patients.Higher BP is associated with higher risk of plaque occurrence.Hypertension is thus an independent risk factor for the formation of atherosclerosis.
