Changes of TXA2 and PGI2 during Postoperative Hypertensive Crisis in Patients with Hypertensive Intracerebral Hemorrhage
- Author:
WANG ZHI
1
;
WANG CHAO
;
ZHANG WEIGUANG
;
WANG LAIZANG
;
LEI TING
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
hypertensive intracerebral hemorrhage;
hypertensive crisis;
TXA2;
PGI2
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(1):87-89
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the changes and the roles of TXA2 and PGI2 during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage, 31 cases subject to crani- otomy were divided into three groups: group A, 9 patients with postoperative hypertensive crisis; group B, 13 patients without postoperative hypertensive crisis; and group C, 9 patients without his- tory of hypertension and hypertensive intracerebral hemorrhage. TXA2＞, TXB2＞, 6-keto-PGF1α and PGI2＞ were measured after operation in the three groups respectively. The postoperative blood pres- sure in group A, including SBP and DBP, was elevated more obviously than that in the other two groups. TXA2＞ and PGI2＞ in group A were significantly higher than those in other two groups (P＜0.01). Moreover, the ratio of TXB2＞ to 6-keto-PGF1α in group A was significantly higher than that in other two groups (P＜0.05). The increase of TXA2＞ and the relative inadequacy of prostacyclin, especially 6-keto-PGF1α, may play roles in the postoperative hypertensive crisis. And the increased value of TXB2＞ to 6-keto-PGF1α could provide the basis for diagnosis of postoperative hypertensive crisis.
