MicroRNA-193b expression in newly diagnosed leukemia patients and its significance.
10.7534/j.issn.1009-2137.2013.04.006
- Author:
Li-Ping FAN
1
;
Hao-Bo HUANG
;
Jian-Zhen SHEN
;
Hai-Ying FU
;
Hua-Rong ZHOU
Author Information
1. Department of Transfusion, Fujian Medical University Union Hospital; Fujian Institute of Hematology, Fuzhou 350001, Fujian Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Child;
Child, Preschool;
Female;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
diagnosis;
genetics;
therapy;
Leukemia, Promyelocytic, Acute;
diagnosis;
genetics;
therapy;
Male;
MicroRNAs;
genetics;
Middle Aged;
Tissue Donors;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(4):843-846
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to quantitatively detect the levels of microRNA-193b (miR-193b) in leukemia patients and explore its significance. Real time fluorescent quantitative PCR was used to detect the relative expression level of miR-193b. The expression changes of miR-193b in various types of leukemia were analyzed. Then the relationship among miR-193b expression, parts of laboratory index and the response to chemotherapy was analyzed as well. The results showed that miR-193b expression level in acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML) patients was not lower than that in normal group (P > 0.05). Except for APL, miR-193b expression level in acute myeloid leukemia (AML) patients was lower than that in normal group (P < 0.05). In AML (except for APL) patients, there was no correlation between white blood cell count (P > 0.05), the expression of CD34 (P > 0.05) and miR-193b expression level, but there was negative correlation between chemotherapy response and miR-193b expression level (P < 0.05). It is concluded that miR-193b expression level may be correlated with susceptibility of cells to chemotherapy in AML (except for APL) patients. miR-193b maybe become a new target in AML (except for APL) therapy.
