Mechanisms of Lung Cancer Caused By Cooking Fumes Exposure: A Minor Review.

Author: Chun-Yan WANG ¹ ; Li-Fang LIU ² ; Xiao-Li LIU ¹ ; Wen-Jun CHEN ¹ ; Guo-Ping HE ¹
Author Information

1. Xiangya Nursing School, Central South University, Changsha 410013, China.
2. Organ Transplant Department, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Publication Type:Journal Article
From: Chinese Medical Sciences Journal 2017;32(3):193-197
CountryChina
Language:English
Abstract: Cooking fumes (CFs) are mixtures of many toxic components, such as aldehydes, heterocyclic amines, polycyclic aromatic hydrocarbons, fat aerosols and particulate matters. CFs exposure has been proven to be associated with many diseases. Lung cancer takes the leading place among the diseases being reported caused by CFs exposure. Molecular and biochemical studies have found that CFs exposure may lead to lung cancer by gene damage, formation of reactive oxygen species, blockage of related proteins' function, and even cell death. However, reviews about the mechanisms of how CFs exposure leads to lung cancer are still lacking. Elucidation of the mechanisms of lung cancer caused by CFs exposure may provide a new insight into the prevention of lung cancer caused by CFs exposure, as well as laying the foundation for the toxicity study of CFs. In this minor review, the mechanisms of how CFs exposure leads to lung cancer were summarized and discussed.