Role of Intestinal Microbiota in Hematopoietic Stem Cell Transplantation - Review.
10.7534/j.issn.1009-2137.2018.01.054
- VernacularTitle:肠道微生物在造血干细胞移植中的作用研究进展
- Author:
Li WANG
1
;
Rui GAO
2
;
Shu-Feng LIU
3
,
4
;
Chun-Ji GAO
5
Author Information
1. Department of Hematology,Chinese PLA General Hospital,Beijing 100853,China; Department of Hematology and Oncology,Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101, Shandong Province, China.
2. Department of Hematology and Oncology,Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101, Shandong Province, China.
3. Department of Hematology and Oncology,Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101, Shandong Province, China. E-mail: wf8439231@
4. com.
5. Department of Hematology,Chinese PLA General Hospital,Beijing 100853,China. E-mail: gaochunji@medmail.com.cn.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2018;26(1):302-306
- CountryChina
- Language:Chinese
-
Abstract:
Graft-versus-host disease (GVHD) and infection are the frequently encountered complications after hematopoietic stem cell transplantation (HSCT), which influence the outcome and limit the widespread application of HSCT. Intestinal microbiota plays an important role in maintaining intestinal immune balance. The diverse levels of intestinal microbiota associated with the incidences of GVHD, infection and the prognosis of HSCT, thus remodeling intestinal microbiota can alleviate GVHD and infection after HSCT. Herein, the recent research progress about the role and the involved mechanisms of intestinal microbiota in HSCT, and the novel manipulation strategies of intestinal microbiota are systematically reviewed.
