Percutaneous Dual-Switching Monopolar Radiofrequency Ablation Using a Separable Clustered Electrode: A Preliminary Study.
10.3348/kjr.2017.18.5.799
- Author:
Tae Won CHOI
1
;
Jeong Min LEE
;
Dong Ho LEE
;
Jeong Hoon LEE
;
Su Jong YU
;
Yoon Jun KIM
;
Jung Hwan YOON
;
Joon Koo HAN
Author Information
1. Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea. jmsh@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Liver;
Hepatocellular carcinoma;
Local ablation therapy;
Radiofrequency ablation;
Therapeutic efficacy
- MeSH:
Carcinoma, Hepatocellular;
Catheter Ablation*;
Electrodes*;
Ethics Committees, Research;
Follow-Up Studies;
Humans;
Informed Consent;
Liver;
Pericardial Effusion;
Prospective Studies;
Retrospective Studies
- From:Korean Journal of Radiology
2017;18(5):799-808
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To prospectively evaluate the safety and therapeutic effectiveness of dual-switching monopolar (DSM) radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC), and to retrospectively compare the results with those of single-switching monopolar (SSM) RFA in a historical control group. MATERIALS AND METHODS: This study was approved by the Institutional Review Board, with informed consent obtained from all patients. Fifty-two HCC patients who underwent DSM-RFA using a separable clustered electrode and dual-generators were prospectively enrolled. Technical parameters, complications, technical success, technical effectiveness, and local tumor progression (LTP) rates were evaluated by means of post-procedural and follow-up imaging. Thereafter, the outcome of DSM-RFA was compared with those of 249 retrospectively included HCC patients treated with SSM-RFA. RESULTS: There were two major complications (3.8%, 2/52) including pleural and pericardial effusion in the DSM-RFA group. The DSM-RFA yielded a 100% technical success rate, a 98.1% technical effectiveness rate, and a 4.3% 2-year LTP rate. In a retrospective comparison between the two groups, DSM-RFA created significantly larger ablation volume (4.20 ± 2.07 cm³/min vs. 3.03 ± 1.99 cm³/min, p < 0.01), and delivered higher energy (1.43 ± 0.37 kcal/min vs. 1.25 ± 0.50 kcal/min, p < 0.01) per given time, than SSM-RFA. There was no significant difference in major procedure-related complications (3.8% vs. 4.4%) and technical effectiveness rate (98.1% vs. 96.4%) between the two groups (p = 1.00). In addition, the 2-year LTP rate of DSM-RFA and SSM-RFA were 4.3% and 10.1%, respectively (p = 0.15). CONCLUSION: DSM-RFA using a separable clustered electrode is safe and provides high local tumor control and good preliminary clinical outcome for small HCCs, which are at least comparable to those of SSM-RFA.
