Immune regulation effect of Chinese medicine of invigorating spleen and kidney detoxification on simian immunodeficiency virus-infected rhesus macaque.
10.19540/j.cnki.cjcmm.2017.0097
- Author:
Miao-Miao ZHANG
1
;
Zhuo-Tao FU
2
;
Jian-Tao CHEN
3
;
Ye CHENG
3
;
Bo-Qiang ZHU
3
;
Lin-Chun FU
3
;
Hong-Yan ZHOU
3
Author Information
1. Department of Chinese Medicine, Hebei University, Baoding 071000, China.
2. The first Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
3. Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510407, China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
immune regulation;
HIV/AIDS
- From:
China Journal of Chinese Materia Medica
2017;42(11):2152-2158
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effect of Chinese medicine of invigorating spleen and kidney detoxification on simian immunodeficiency virus-infected rhesus macaque. Eight SIV rhesus macaques of the same age were randomly divided into Chinese medicine of invigorating spleen and kidney detoxification group(hereinafter referred to as Chinese medicine group) and anti-virus drug(HAART) group. The traditional Chinese medicine and antiviral therapy were given for 8 weeks, and peripheral blood was collected for detection in every 4 weeks. The results showed that Chinese medicine of invigorating spleen and kidney detoxification could not obviously decrease plasma viral load as HAART, but it can increase CD4 number in peripheral blood, especially the CD4 naive cells, and increase the number of CD4 and CD8 cells, enhance the immune response to pathogens. Therefore, it delayed the occurrence and development of spleen deficiency to a certain extent, indicating that the medicine had immune regulation effect, with considerable clinical value and application prospects.
