Impact of pre-procedural plasma brain natriuretic peptide level on atrial fibrillation recurrence post radiofrequency catheter ablation
10.3760/cma.j.issn.0253-3758.2012.01.009
- VernacularTitle:射频导管消融治疗阵发性心房颤动患者的血浆B型利钠肽水平
- Author:
Yan-Yan JIN
1
;
Xin-Yong ZHANG
;
Xiao-Ling ZHU
;
Chang-Sheng MA
;
De-Yong LONG
Author Information
1. 首都医科大学附属北京安贞医院
- Keywords:
Atrial fibrillation;
Natriuretic peptide,brain;
Catheter ablation
- From:
Chinese Journal of Cardiology
2012;40(1):39-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective Brain natriuretic peptide(BNP)levels are elevated in patients with atrial fibrillation(AF).The aim of this study is to investigate the relation between the pre-procedural BNP level and the incidence of recurrence AF after circumferential pulmonary vein ablation(CPVA).Methods Plasma BNP level was measured before CPVA in 69 consecutive symptomatic paroxysmal AF(PAF)patients without heart failure symptom.Atrial thrombus was detected by transesophageal echocardiography in 15 patients and CPVA was not performed in these patients.CPVA was successful in the remaining 54 patients and followed up for 3 months.All patients were asked to keep a log of the duration and frequency of their symptoms and underwent 24 h ECG monitoring at least once per month after the ablation.Results At the end of follow up,39 patients were free of AF recurrence(successful group)and 15 patients experienced AF recurrence(failure group).BNP concentration was below the heart failure range(＜ 500 ng/L)in 69.6％patients,but exceeded the normal range(0-144 ng/L)in 59.4％ patients.Median baseline BNP level wassignificantly higher in failure group than in successful group(371.6 ng/L vs.97.4 ng/L,P =0.001).Left atrial(LA)dimension was also larger in failure group than in successful group[(53.3 ± 15.1)mm vs.(45.2 ± 11.2)mm,P =0.036].Moreover,BNP level was positively correlated with LA dimension(r =0.574,P ＜ 0.01).Conclusion The pre-procedural BNP level and LA dimension are predictive of successful CPVA for PAF patients.
