Distribution of chemical compounds of Fufang Xueshuantong capsule in eyes and kidney of beagle dogs.

Author: Mei-Fang JIANG ¹ ; Qin-Hui WANG ¹ ; Huan-Huan PANG ¹ ; Yue TIAN ¹ ; Xiao-Ye WANG ¹ ; Lu SUN ¹ ; Wei GAO ¹ ; Jian-Mei HUANG ¹
Author Information

1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
Publication Type:Journal Article
Keywords: Fufang Xueshuantong capsule; HPLC LTQ-Orbitrap; eyeball; kidney; notoginsenosides
From: China Journal of Chinese Materia Medica 2016;41(20):3846-3851
CountryChina
Language:Chinese
Abstract: Diabetic retinopathy(DR) and diabetic nephropathy(DN) are the most common complications of diabetes, and the main causes of death and disability of diabetes. Clinical reports showed that Fufang Xueshuantong capsule(FXT) had effective curative effect on DR and DN, but there was no report on the distribution of chemical compounds of FXT in beagle dog eyes and kidneys. In this study, FXT was given by gavage administration in Beagle dogs for 3 days, and then their eyeballs and kidneys were taken. The chemical compounds in beagle dog eyes and kidneys were detected by HPLC LTQ-Orbitrap technology. Furthermore, by comparing with the data from retrieving literature and references, the chemical compounds were identified by the accurate mass, retention time (tR), and MS/MS. Fourteen and 19 types of notoginsenosides were respectively identified in eyeballs and kidneys in this study, and these results could lay foundation for clarifying the effective ingredients of FXT in treatment of DR and DN.