Efficacy and Safety of Posaconazoleon for Primary Antifungal Prophylaxis against Invasive Fungal Disease in Patients with Stem Cell Transplantation.
- VernacularTitle:泊沙康唑一级预防造血干细胞移植患者侵袭性真菌病的效果及安全性评估
- Author:
Ya-Mei WU
1
;
Yong-Bin CAO
1
;
Xiao-Hong LI
1
;
Li-Xin XU
1
;
Bei YAN
1
;
Song-Wei LI
1
;
Hai-Tao WANG
1
;
Ya-Hui GAO
1
;
Tian-Tian ZHANG
1
;
Ya-Qian ZHANG
1
;
Li WANG
1
;
Xiao-Xiong WU
2
Author Information
- Publication Type:Journal Article
- From: Journal of Experimental Hematology 2017;25(3):885-889
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy and clinical safety of posaconazoleon primary antifungal prophylaxis against invasive fungal disease (IFD) in patients with stem cell transplantation.
METHODSAt the start from preconditioning regimen, 45 patients without IFD were administered with posaconazoleon until neutrophils greater than 0.5×10/L, 35 patients treated with micafungin were enrolled in control group. The incidence, risk factors of IFD and side effects of medicines were evaluated.
RESULTSOf the total 80 patients, 13(16%) had IFD within 100 days after allo-HSCT. The overall survival was significantly different between patients with or without IFD by Kaplan-Meier survival curve analysis (P<0.05). Out of the 45 cases in posaconazoleon group, IFD occurred in 4 cases (9%). In contrast, the incidence of IFD in control group was 26%(9 out of 35) (P<0.05). The risk factors of IFD and side effects were not significantly different between 2 groups(P>0.05).
CONCLUSIONThe primary prevention efficancy of IFD by posaconazoleon after allo-HSCT is much better than that of micafungin with well tolerability and satisfactory efficacy.
