Experimental study on the reconstruction of mandibular defects with a new bioactive artificial bone nano-hydroxyapatite/polyamide-66 in dogs.
- Author:
Qian ZHENG
1
;
Li-Wei ZHOU
;
Shi-Cheng WEI
;
Yu-Bao LI
;
Jie WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Substitutes; Dogs; Durapatite; Male; Mandible; surgery; Nylons; Reconstructive Surgical Procedures
- From: Chinese Journal of Stomatology 2004;39(1):60-62
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study was designed to investigate reconstruction of segmental defect in the mandible using a new bionic materials of nano-hydroxyapatite -polyainides-66 (n-HA/PA66).
METHODSTwo defects (15 mm x 10 mm x 5 mm) were created in the mandibular bodies of dogs. One of defects was reconstructed with n-HA/PA66, another not repaired as a blank control. At 2, 4, 8, 12, 16 weeks after operation. Evaluation of effects of n-HA/PA66 on reconstruction of the mandibular defects was carried out by means of radiography and histology.
RESULTSFrom 2 to 8 weeks after operation, some fiber tissue grew into the space between n-HA/PA66 and mandibular bone. The ossification was observed at 12 weeks post-operation. At 16 weeks, the n-HA/PA66 was connected directly to the mandibular bone by the newborn bone.
CONCLUSIONSThe new artificial bone of n-HA/PA66 has the effects of osteoconduction and osteoinduction, with a good biocompatibility and is an ideal bone substitute material for reconstruction of mandibular defect.
