Androgen receptor gene polymorphisms and male infertility.
- Author:
Qing ZHOU
1
;
Qiu-Yue WU
1
;
Xin-Yi XIA
1
;
Hao-Qin XU
2
Author Information
1. PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
2. Institute of Family Planning Science of Jiangsu Province, Nanjing 210029, China.
- Publication Type:Journal Article
- Keywords:
androgen;
androgen receptor;
male infertility;
spermatogenesis
- From:
National Journal of Andrology
2016;22(10):928-931
- CountryChina
- Language:Chinese
-
Abstract:
The androgen receptor (AR), as a ligand-dependent transcription protein and a member of the steroid receptor superfamily widely present in the body, is involved in the adjustment of the function of androgens and plays an important role in spermatogenesis. Androgens participate in spermatogenesis by binding AR and initiating the expression of the target gene. The polymorphisms of the AR gene may change the structure of AR and affect its avidity of binding androgens, making their downstream target genes unable to transcribe proteins. With the development of DNA sequencing techniques, studies on the association of the polymorphisms of the AR gene with male infertility have become a hot topic.
