Blood pressure lowering efficacy of telmisartan and amlodipine taking on the morning or at bedtime: ABPM results
10.3760/cma.j.issn.0253-3758.2013.06.010
- VernacularTitle:动态血压监测评估四种不同时间联合治疗方案的降压效果
- Keywords:
Hypertension;
Chronotherapy;
Trentment outcome
- From:
Chinese Journal of Cardiology
2013;41(6):484-487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the blood lowering effect of telmisartan and amlodipine taking on the morning or at bedtime in hypertensive patients.Methods A total of 108 individuals with hypertension (grade 2 or above) were randomized to receive telmisartan and amlodipine in one of the following four therapeutic schemes:Group A (26 cases):both medications taken on the morning; Group B (28 cases):both medication taken at bedtime; Group C (27 cases):telmisartan on the morning and amlodipine at bedtime ; or Group D (27 cases):amlodipine on the morning and telmisartan at bedtime.ABPM was performed before and after 8 weeks treatment.Results BP was significantly reduced in 4 groups and the value of 24 hours SBP/DBP decline for each group after treatment was 29.94/16.32,31.37/18.35,29.49/17.30 and 25.80/15.51 mm Hg (1 mm Hg =0.133 kPa) respectively (P＜0.05 vs.baseline).SI (smooth index) of 24 hours SBP/DBP was 1.79/1.34,2.07/1.54,1.70/1.43 and 1.55/1.32 respectively (P ＞ 0.05).The night-time BP decline and the distributive difference of dipper,non-dipper,extreme dipper and reverse dipper pattern were similar among groups at both baseline and after various treatment regimens (all P ＞ 0.05).Morning blood pressure surge (MBPS) after treatment in group B declined more significantly than other groups (P ＜ 0.05).Conclusion Telmisartan/amlodipine administered either on the morning or at bedtime can effectively reduce blood pressure.The efficacy of BP lowering is independent of the drug taking time.There is a trend both in better BP lowering and less BP variability when two medications are administered at bedtime.
