Value of cardiopulmonary exercise test in assessment of cardiac function of patients with pulmonary hypertension
10.3760/cma.j.issn.0253-3758.2013.06.013
- VernacularTitle:心肺运动试验在评价肺动脉高压患者心功能中的应用
- Author:
Qin LUO
1
;
Zhi-Hong LIU
;
Xiu-Ping MA
;
Zhi-Hui ZHAO
;
Qing GU
;
Chang-Ming XIONG
;
Qing ZHAO
Author Information
1. 100037,中国医学科学院院北京协和医学院 阜外心血管病医院 心血管疾病国家重点实验室 肺血管病诊治中心
- Keywords:
Hypertension,pulmonary;
Ventricular function;
Exercise test
- From:
Chinese Journal of Cardiology
2013;41(6):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of peak oxygen consumption in assessment of heart function of patients with pulmonary hypertension.Methods From September 2010 to April 2012,101 patients [29 male,mean age:(32.6 ± 11.4)years] with pulmonary hypertension diagnosis by right heart catheterization were enrolled.Correlations among peak oxygen consumption,New York Heart Association (NYHA) class,NT-proBNP,6 minute walking distance (6MWD) and cardiac index are analyzed.Results There were 44 cases with NYHA class Ⅱ (43.6％),49 cases with NYHA class Ⅲ (48.5％),mean 6MWD was (421 ± 91)m,NT-proBNP was (1262 ± 816) ng/L,pulmonary vascular resistance was (1031 ±582) dyn · s-1 · cm-5,CI was (3.5 ± 2.3) L · min-1 · m-2,peak oxygen consumption was(13.8±4.1)ml · min-1 · kg-1.6MWD,pulmonary vascular resistance and peak oxygen consumption were related to CI (r =0.299,-0.541,0.341,respectively,all P ＜ 0.05),but NYHA class and NT-proBNP were not correlated to CI.Multiple regression analysis demonstrated that peak oxygen consumption (B =0.135,P =0.004) but not 6MWD was correlated with CI after adjusting age,sex and pulmonary vascular resistance.ROC analysis found that the sensitivity and specificity using peak oxygen consumption ＜ 15.2 ml · min-1· kg-1 as a cut-off value was 92.6％ and 57.5％,respectively,for diagnosing severe heart dysfunction.Conclusions The correlation between peak oxygen consumption and CI is better than that of NYHA class,6MWD,and NT-proBNP with CI.Peak oxygen consumption less than 15.2 ml · min-1 · kg-1 could be used to detect reduced CI in patients with pulmonary hypertension.
