Impact of baseline pulse pressure on new-onset cardio-and cerebrovascular events in diabetic population
10.3760/cma.j.issn.0253-3758.2013.06.016
- VernacularTitle:脉压水平对糖尿病人群新发心脑血管事件的影响
- Keywords:
Pulse pressure;
Diabetes mellitus;
Risk assessment
- From:
Chinese Journal of Cardiology
2013;41(6):514-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the association between baseline pulse pressure (PP)level and new-onset cardio-cerebrovascular events in diabetic population.Methods Physical examination data between July 2006 to October 2007 from a total of 101 510 employees of Kailuan Group were reviewed,8306 subjects with a fasting plasma glucose level of ≥ 7.0 mmol/L or with confirmed diabetes diagnosis and were enrolled in this prospective cohort study.Subjects were followed up for 38-53 (48.1 ± 3.1) months and the cardio-cerebrovascular events were obtained every six months,association between baseline PP and new-onset cardio-cerebrovascular events in the diabetic population were analyzed.Results (1) Incidences of total cardio-cerebrovascular events in the PP groups were 3.4％,2.8％,4.5％,6.4％,respectively.Incidences of cerebral infarction events and myocardial infarction were 2.1％,1.6％,2.9％,3.9％ and 1.1％,0.7％,1.0％,1.7％,respectively.(2) Multivariate Cox' s proportional hazards regression analysis indicated that baseline PP group was the risk factor for total cardio-cerebrovascular events,cerebral infarction events and myocardial infarction,and the risk for all the events of the PP≥60 mm Hg (1 mm Hg =0.133 kPa) group was increasing.The values of RR(95％ CI) were 1.88 (95％ CI 1.34-2.65,P ＜ 0.01),1.92 (95 ％ CI 1.23-2.99,P ＜ 0.01) and 1.52 (95 ％ CI 0.82-2.81,P ＞ 0.05) after adjust the other factors.(3) In line with increasing level of baseline PP,age,BMI,SBP,DBP,HDL-C,and hs-CRP levels significantly increased in this diabetic population (P ＜ 0.01 or P ＜ 0.05).Conclusion The level of high baseline PP is a risk factor for new-onset cardio-cerebrovascular events in diabetic population.
