Meta analysis on the association of CYP11B2 gene polymorphism and essential hypertension in Chinese Han population
10.3760/cma.j.issn.0253-3758.2013.09.015
- VernacularTitle:CYP11B2多态性与中国汉族原发性高血压关联的荟萃分析
- Author:
Wen-Jing YE
1
;
Ling ZHENG
;
Zheng-Hua WANG
;
Huan-Huan CHEN
Author Information
1. 350108福州,福建医科大学公共卫生学院流行病与卫生统计学系;福建省人兽共患重点实验室(福建省疾病预防与控制中心)
- Keywords:
Hypertension;
Polymorphism,single nucleotide;
meta-analysis
- From:
Chinese Journal of Cardiology
2013;41(9):795-799
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between CYP11B2 gene polymorphism and essential hypertension,blood pressure level in Chinese Han population by meta-analysis.Methods After searching database,the research quality was quantified according to NOS.Genetic model,heterogeneity,publication bias,overall OR/standardized mean difference (SMD) and 95％ CI were explored by Stata,19 studies including 9249 subjects were included in this meta-analysis.Results Compared to control group,0R(95％ CI) of CC vs.TT,CT vs.TT,CC vs.CT in essential hypertensive patients were 1.022(95％ CI:0.879-1.190),1.108 (95％ CI:0.951-1.291),1.050(95％ CI:0.995-1.109),respectively; SMD (95％CI) was 0.315 (0.066-0.565,P ＜ 0.05) for systolic pressure derived CC vs.TT,and 0.088 (0.014-0.162,P ＜ 0.05) for CT vs.TT.Conclusion Individuals with-344C CYP11 B2 allele are at higher risk of increased systolic blood pressure,but there is no evidence showing association between CYP11 B2 polymorphism and susceptibility of essential hypertension in Chinese Han population.
