The impact of cardiac resynchronization therapy on left ventricular diastolic function evaluated by speckle tracking imaging in patients with dilated cardiomyopathy
10.3760/cma.j.issn.0253-3758.2013.11.010
- VernacularTitle:斑点追踪成像评估心脏再同步化治疗对扩张型心肌病患者左心室舒张功能的影响
- Author:
Juan LU
1
;
Min DAI
;
Da-Jun QIAN
;
Chang-Ying ZHANG
;
Li-Jun CAO
;
Ru-Xing WANG
Author Information
1. 214023,南京医科大学附属无锡市人民医院心脏中心
- Keywords:
Cardiomyopathy,dilated;
Echocardiography;
Ventricular function,left;
Cardiac synchronization therapy
- From:
Chinese Journal of Cardiology
2013;41(11):940-944
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) diastolic function measured by speckle tracking imaging (STI) in patients with dilated cardiomyopathy (DCM).Methods CRT was performed in 21 DCM patients [15 male,mean age:61.2 ± 11.2 (49-82) years].LV synchronization,LV systolic function and LV diastolic function were evaluated with conventional echocardiography,tissue Doppler imaging and STI before and 6 months after CRT.NYHA heart function was also assessed.Clinic Response to CRT was defined as improvement of more than 1 NYHA class.Response to CRT in echocardiography was defined as ≥ 15％ reduction in LV end systolic volume at 6 months post CRT.Results There were 16 responders and 5 non-responders at 6 months post CRT.In terms of diastolic function,conventional echocardiography derived deceleration time was both prolonged in nonresponders and responders.At 6 months post CRT,STI derived LV isovolumetric diastolic strain rate [(0.19 ±0.11) /s vs.(0.14 ± 0.09) /s,P ＜ 0.001] was significantly increased while early diastolic mitral valve blood flow velocity/left ventricular isovolumetric diastolic strain rate (680 ± 600 vs.787 ± 690,P＜0.04) was significantly reduced in responder group while remained unchanged in non-responder group.Furthermore,left ventricular isovolumetric diastolic strain rate negatively correlated with plasma brain natriuretic peptide level (r =-0.68,P ＜ 0.05).Conclusion In CRT responders of DCM patients,LV diastolic function is significantly improved and this change could be detected more effectively by STI derived LV diastolic function parameters.
