Association between plasma leptin level and periodontal parameters in patients with aggressive periodontitis

VernacularTitle:侵袭性牙周炎患者血浆瘦蛋白水平与牙周临床指标的相关性研究
Author: Yun-Yu LIU ¹ ; Xin ZHANG ; Dong SHI ; Zhi-Bin CHENG ; Huan-Xin MENG
Author Information

1. 100081,北京大学口腔医学院·口腔医院牙周科
Keywords: Aggressive periodotitis; Leptin; Attachment loss
From: Chinese Journal of Stomatology 2013;48(1):3-6
CountryChina
Language:Chinese
Abstract: Objective To detect the plasma leptin levels in patients with aggressive periodontitis (AgP) and to analyze the relationship between circulating leptin level and periodontal condition.Methods A total of 97 patients with AgP and 44 healthy controls were recruited.Detailed clinical examinations were conducted and clinical parameters such as bleeding index (BI),probing depth (PD),attachment loss(AL) were recorded.Plasma leptin level was measured by enzyme-linked immunosorbnent assay.Results The plasma leptin level in AgP group was significantly higher than that of control subjects [(20.0 ± 4.3) μg/L vs.(7.5 ± 1.3) μg/L,P ＜ 0.01)].The plasma leptin level was positively related to BI,PD and AL,and the r values were 0.647,0.596 and 0.632 respectively (P＜0.01).Conclusions Plasma leptin concentration in AgP patients was significantly elevated compared with healthy controls.Circulating leptin level was positively related to periodontal parameters including BI,PD and AL.