Cytogenetic characteristics of 163 children with acute lymphoblastic leukemia.
- Author:
Xiao-Hong GUO
1
;
Xiao-Wen ZHAI
2
;
Xiao-Wen QIAN
2
;
Hong-Sheng WANG
2
;
Cui-Qing FAN
2
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Cytogenetic Analysis; Fusion Proteins, bcr-abl; Humans; In Situ Hybridization, Fluorescence; Infant; Precursor Cell Lymphoblastic Leukemia-Lymphoma
- From: Journal of Experimental Hematology 2015;23(2):312-317
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo further understand the cytogenetic characteristics of pediatric acute lymphoblastic leukemia (ALL).
METHODSCytogenetic abnormalities of 163 children with newly diagnosed ALL (0-17 years of age) were evaluated by conventional cytogenetic analysis and fluorescent in situ hybridization findings.
RESULTSChromosome abnormalities were detected in 87.7% of patients (143/163). The ploidy levels most frequently observed among ALL patients were high hyperdiploidy (51-67 chromosomes) (45 cases, 27.6%), Chromosomes X and 21 were gained in 100% of these cases. The most common genetic alterations were t(12;21)/ETV6/RUNX1 (26 cases, 16.0%), followed by t(1;19)/TCF3/PBX1 (13 patients, 8.0%), t(4;11)/MLL rearrangement and t(8;14) IGH/MYC (6 cases, 3.7%), t(9;22)/BCR/ABL(2 cases, 1.2%), and iAMP21 (1 patient, 0.6%). The no-classical structural abnormalities included dup(1q) in 20.2%, del(6q) and del(9p) in 10.4%, del(12p) in 12.9% and del(13q) in 5.5%. The incidences of t(12;21), t(1;19), t(9;22) and high hyperdiploidy were consistent with reports in Western children (P>0.25). The incidence of (9;22) seemed to be much lower in our study than that in Korea (1.5% vs 9.5%, P<0.005).
CONCLUSIONCytogenetic findings of childhood ALL patients are similar to that of Western countries, it seems no more adverse risk factors.
