The effect of entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and its relationship to HBeAg sero-conversion
10.3760/cma.j.issn.1003-9279.2008.02.014
- VernacularTitle:恩替卡韦治疗对慢性乙型肝炎患者特异性细胞免疫功能的影响及其与HBeAg血清学转换的关系
- Author:
Jian-Xiang LI
1
Author Information
1. 广东省深圳市罗湖区人民医院
- Keywords:
Entecavir;
Hepatitis B virus;
Immunity,cellular
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(2):122-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and its relationship to HBeAg sero-conversion. Methods Serum aminotransferase ( ALT), HBV DNA and HBeAg were monitored before the after entecavir treatment. At the same time point, HBV-specific T cell proliferation was determined by [3 H] T-dR incorporation assay, while HBV-specific IFN-γ secretion was measured by ELISA. Result The level of HBV DNA and ALT was significantly decreased after entecavir treatment. Same is the titer of HBeAg. In addition, HBeAg sero-conversion was observed in some of them, in whom the HBV-specific T cell proliferation and IFN-γ production were significantly increased. Conclusion Entecavir treatment resulted in increased HBV-specific immunity along with the inhibition of HBV replication.
