Increased level of prostate-specific antigen: a diagnostic marker of hyperandrogenism women.
- Author:
Guo-Hong WANG
1
;
Rui-Ji XU
;
Zhong-Shu ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Body Mass Index; Case-Control Studies; Female; Humans; Hyperandrogenism; blood; diagnosis; Prostate-Specific Antigen; blood; Sex Hormone-Binding Globulin; Young Adult
- From: National Journal of Andrology 2009;15(11):1028-1030
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine whether the increased level of serum prostate-specific antigen (PSA) could be used as a diagnostic marker of hyperandrogenism in women.
METHODSForty-five female patients with hyperandrogenism and 50 healthy control women were detected for the levels of serum PSA, testosterone (T), sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-S). The results were statistically analyzed.
RESULTSThe level of serum PSA was found to be significantly higher in the hyperandrogenism patients than in the healthy controls (9.72 +/- 1.39 pg/ml vs 3.56 +/- 0.44 pg/ml, P < 0.01), and it showed a weak positive correlation with T (r = 0.226, P < 0.05) and DHEA-S (r = 0.255, P < 0.05), and a weak negative correlation with SHBG (r = -0,228, P < 0.05).
CONCLUSIONThe increased level of PSA could be used as a diagnostic marker of hyperandrogenism in females.
