Expression of integrin-β1 in oral leukoplalkia and early invasive carcinoma and its relationship with cell proliferation
10.3321/j.issn:1002-0098.2008.10.009
- VernacularTitle:口腔白斑癌变过程中整合素β1的表达及其与细胞增殖的关系
- Author:
Jian-Wei SHANG
1
;
Yan GAO
Author Information
1. 北京大学口腔医学院(口腔医院)
- Keywords:
Leukoplakia,oral;
Antigens,CD29;
Cell proliferation;
Early invaaive carcinoma
- From:
Chinese Journal of Stomatology
2008;43(10):608-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of integrin-β1 in oral leukoplakia and early invasive carcinoma.Methods The expression of integrin-β1 and Ki-67 was examined in 12 normal oral mucosa,10 simple hyperplasia,24 epithelial dysplasia and 14 early invasive carcinoma by immunohistochemistry.Results In normal and simple hyperplasia epithelium,integrin-β1 was mostly expressed in the basal cell membrane,and Ki-67 in the nuclei of basal and the parabasal layers. In dyspla siaepithelium and early invasive carcinoma,integrin-β1 showed membrane staining and Ki-67 showed nuclear staining in dysplastic basal cells,sprickle cells and SCC cells. Integrin-β1 and Ki-67 were overexpressed in 7 and 10 of 24 dysplasia cases and in 8 of 14 early invasive carcinoma cases respectively. There was a significant difference in integrin-β1 and Ki-67 expression among the four groups (χ2=10.651,P=0.014;χ2=14.831,P=0.002),in integrin-β1 expression among normal oral mucosa,simple hyperplasia and early invasive carcinoma (P=0.008,P=0.013)and in Ki-67 expression among normal oral mucosa and dysplasia,early invasive carcinoma (P=0.026,P=0.001),and among simple hyperplasia and early invasive carcinoma (P=0.005).A significant correlation between integrin-β1 and Ki-67 (R=0.442,P＜0.01)was found.Conclusions Integrin-β1 showed increased staining in dysplasia epithelium ceils and SCC cells,and may correlate to the proliferation of the dysplasia cells.
