Study on active constituents against Alzheimer's disease from Valeriana amurensis.
- Author:
Ying-Ying WAN
1
;
Chang-Fu WANG
1
;
Qiu-Hong WANG
1
;
Yang XIAO
1
;
Zhi-Bin WANG
1
;
Hai-Xue KUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer′s disease; Valeriana amurensis; active constituents; structure identification
- From: China Journal of Chinese Materia Medica 2016;41(9):1649-1653
- CountryChina
- Language:Chinese
- Abstract: In this study, the chemical constituentsfrom Valeriana amurensis AD-effective fraction were investigated based on the effect of Valeriana amurensis on Alzheimer's disease (AD) in previous study. Valeriana amurensis was extracted with 75% ethanol and the obtained extract were extracted and subjected to AB-8 macroporous resin column to obtain the AD-effective fraction of Valeriana amurensis. 9 compounds (1-9) were isolated with silica gel, ODS column chromatography and preparative HPLC. The structures of these compounds were determined as 6-hydroxy-7-(hydroxymethyl)-4-methylenehexahydrocyclopenta[c]-pyran-1(3H)-one (1), suspensolide F (2), loganin(3), α-morroniside(4), β-morronisid (5), partinovalerosidate (6), zansiumloside A (7), (-)-angelicoidenol-2-O-β-D-glucopyranoside (8), citroside A (9). Compounds 6-9 were isolated from the valerian genus for the first time and further investigated the anti-AD effect of compounds 1-9 in vitro found that compound 2 and 6 protected the PC12 cells from injury significantly.
