Two new lactone derivatives from an endophyte Diaporthe sp. XZ-07 cultivated on Camptotheca acuminata.

Author: Cheng SHI ¹ ; Lin YUAN ¹ ; Xiang LIN ² ; Pei-Ji ZHAO ²
Author Information

1. Chemical Science and Technology Department, Kunming University, Kunming 650214, China.
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
Publication Type:Journal Article
Keywords: Camptotheca acuminata; Diaporthe sp.; cytotoxic activities; endophytic fungus; lactone
From: China Journal of Chinese Materia Medica 2016;41(10):1860-1863
CountryChina
Language:Chinese
Abstract: To study the secondary metabolites and their cytotoxic activities of an endophytic fungus Diaporthe sp. XZ-07cultivated on Camptotheca acuminata. Colum chromatography by RP-18, Sephadex LH-20 and silica gel was used to isolate and purify the chemical constituent. Two new compounds were isolatedand identified as 5-((E)-1,4,5-trihydroxyhex-2-enyl)furan-2(5H)-one(1)and(5Z)-5-(2,3,4,5-tetrahydroxyhexylidene)furan-2(5H)-one(2)by spectroscopic analysis. Cytotoxic activities were evaluated by MTT method. Compound 1 showed strong inhibitory activity against Human cervical carcinoma cell line Hela, and compound 2 showed strong inhibitory activity against breast cancer cell line MCF-7, Human neuroblastoma SH-SY5Y and Lewis lung carcinoma cells 3LL.