Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma
10.3760/cma.j.issn.1673-0860.2011.04.009
- VernacularTitle:基质金属蛋白酶及组织金属蛋白酶抑制剂在鼻腔鳞状细胞癌中的表达及意义
- Author:
Yan ZHENG
1
;
Jun DING
;
Chun-Li WANG
;
Shou-Shan JIAO
;
Li-Ming QU
;
Bahargul
;
Hui BAO
;
Xiao CHEN
Author Information
1. 新疆医科大学第二附属医院
- Keywords:
Carcinoma,squamous cell;
Nose neoplasms;
Matrix metalloproteinase2;
Matrix metalloproteinase 9;
Tissue inhibitor of metalloproteinase-1;
Tissue inhibitor of metalloproteinase-2
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(4):299-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of matrix metalloproteinase (MMP)2, MMP-9, tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP-2 in nasal cavity squamous cell carcinoma and their signification. Methods Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasal tissue were detected for MMP-2, MMP-9, TIMP-1, TIMP-2 by immunohistochemistry technique (S-P), and their relationship between the expression of MMP-2, MMP-9, TIMP-1, TIMP-2 and some clinical symptoms were analyzed. The SPSS 12. 0 software was used to analyze the data. Results The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52. 0% (26/50), which was significantly higher ( x2 = 6. 00, P ＜0. 05 ) than those [28.0% (14/50)] in the normal nasal tissue. The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0% (29/50), which was significantly higher ( x2 = 12. 8, P ＜ 0. 05 ) than those [10. 0% (5/50)] in the normal nasal tissue. The positive ratio of expression of TIMP-1 in two groups was 74. 0% (37/50), 56. 0% (28/50) respectively.There was no difference between two groups ( x2 = 0. 51, P ＞ 0. 05 ). The positive ratio of expression of TIMP-2 in two groups was 26. 0% ( 13/50), 20% (10/50) respectively. There was no difference between two groups( x2 = 3.35, P ＞ 0. 05). Conclusions There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues. Both MMP and TIMP, especially the unbalance of MMP and TIMP, have prognostic value in nasal cavity squamous cell carcinoma.
