Predictive study of HBsAg in different stages of neonatal venous blood on failure of blocking HBV mother to infant transmission
10.3760/cma.j.issn.1003-9279.2011.05.007
- VernacularTitle:新生儿不同时期静脉血HBsAg含量对HBV母婴传播阻断失败的预测研究
- Author:
Wei YI
1
;
Ming-Hui LI
;
Yu-Hong HU
;
Feng LIU
;
Yang-Li ZHANG
;
Xue-Jing LIU
;
Hong-Xiao HAO
;
Shu-Jing SONG
;
Ying LIU
;
Xing-Hong LI
;
Ji-Yun SUN
;
Min LIU
;
Jun CHENG
;
Yao XIE
Author Information
1. 首都医科大学附属北京地坛医院
- Keywords:
Hepatitis B surface antigens;
Disease transmission,vertical;
Hepatitis B virus;
Hepatitis B vaccines
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(5):338-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this study,we discuss the predictive value of different content of HBsAg in different stages of neotal venous blood on failure of blocking mother to infant transmission of HBV.Methods 150 infants born of chronically HBV infected mothers who were positive of both HBsAg and HBeAg and who also had a HBV DNA virus load above 105 copies/ml were enrolled.These infants were given hepatitis B virus immune globin (HBIG) 200 IU immediately after birth and were given hepatitis B vaccine 10 or 20 μg at brith,1 month and 6 months after birth.HBV serological index of these infants were test at birth,1 month and 7 months after birth respectively.Different content of HBsAg in different stages of neonatal venus blood were analyzed to predict the failure of blocking mother to infant transmission of HBV.Results 11 infants failed in blocking of HBV mother to infant transmission.The positive rate of HBsAg at birth,1 month and 7 months after birth were 41.26％,10.49％ and 7.69％ respectively,and were 97.90％,65.73％ and 13.29％ of HBeAg.The positive predictive value of HBsAg≥0.05 and HBsAg≥ 1 IU/ml at birth were 18.64％ and 70％ respectively,and were 73.33％ and 100％ one month after birth.Conclusions Infants with HBsAg ≥ 1 IU/ml at birth should be suspicious of failure on blocking HBV mother-to-infant transmission and it should be more credible if the infant has HBsAg≥ 1 IU/ml one month after birth.How to improve the blocking rate of neonates who were positive of HBsAg at birth and one month after birth should be the focus of our future research.
