Investigate the impact of hepatitis B virus infection on sperm DNA integrity

VernacularTitle:乙型肝炎病毒感染对精子DNA完整性影响的研究
Author: Jian-Wei CHEN ¹ ; Yun CUI ; Xiao-Xia ZHANG
Author Information

1. 浙江中医药大学附属宁波市中医院
Keywords: Hepatitis B; Spermatozoa; DNA; Chromatin
From: Chinese Journal of Experimental and Clinical Virology 2011;25(5):345-347
CountryChina
Language:Chinese
Abstract: Objective Investigated the impact of HBV infection on sperm DNA integrity and its applied significance.Methods 12 cases infertility male with HBV infection in patient group and 11 cases of normal male without HBV infection in the control group were by SCD and CASA.Results The DFI in the patient group was (23.4 ± 10.2 ) ％,while it was in the control group was ( 11.6 ± 5.9) ％.The difference of the DFI in these two groups was significantly,P ＜ 0.01.The sperm concentration and forward motility (a + b) in the patient group were lower than that in the control group,P ＜0.01.There were also significantly of the normal sperm and sperm activity between the two groups.Conclusion HBV infection not only affected the conventional semen parameters,but also caused serious damage on sperm DNA.