Demonstration of nested case-control study design in mechanisms research of allergic reaction of tanreqing injection.
- Author:
Peng-Yang XIE
;
Yan-Ming XIE
;
Lian-Xin WANG
;
Yan-Peng CHANG
;
Shao-Yong LIU
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Drugs, Chinese Herbal;
administration & dosage;
adverse effects;
Female;
Humans;
Hypersensitivity;
diagnosis;
metabolism;
Interleukin-10;
metabolism;
Interleukin-2;
metabolism;
Interleukin-4;
metabolism;
Interleukin-6;
metabolism;
Male;
Prospective Studies;
Young Adult
- From:
China Journal of Chinese Materia Medica
2014;39(18):3567-3570
- CountryChina
- Language:Chinese
-
Abstract:
The paper is focused on the clinical applications of Tanreqing injection after listing, detecting and analyzing the related blood indicators of patients with allergic reactions based on prospective, multi-center, large sample, registration-type clinical safety monitoring nested case-control study (NCCS) to explore the possible mechanisms of allergic reaction of Tanreqing injection, 3 006 patients cases used with Tanreqing injection were monitored, including 3 cases of adverse reactions and 2 cases of allergic reactions. Each patient of allergic reactions, according to the ratio of 1:4 matches four cases of not adverse reactions as a control group of patients, while 5 healthy and 5 cases of volunteers into the healthy group. We examined the correlation detection of cases of allergic reactions among groups such as T-IgE, IgA, IgG, C3, C4, IFN-g, IL-2, IL-4, IL-6, IL-10. Allergic reactions of Tanreqing injection may be mediated by IgE as type I based on existing research data. This results and conclusions will promote the justifiability and safety of clinical applications.
